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Dubin Lab | Protein Crystallography
We are primarily interested in studying the interactions of proteins and low-molecular substances in the topic of carcinogenesis and bacterial pathogenesis. Currently we realize our own projects involving structural characterization of kinases of essential role cancer, p53 pathway, bacterial proteases of unknown catalytic mechanism and staphylococcal proteases. In parallel to the crystallographic studies we also develop aptamer selection techniques (especially single-stranded DNA) against targets of importance in cancer. In addition to our own research, we are also involved in broad scientific collaboration and cooperation with the industry on other subjects whenever problem scan be solved by X-ray crystallography of proteins. We invite anyone interested in collaboration.
More information about Dubin Lab
Glatt Lab | Max Planck Research Group
We study different translation control mechanisms, which regulate the production of specific sets of proteins by chemical modifications of tRNA molecules. Every protein in the cell is produced by the ribosome, which uses transfer RNA (tRNA) molecules to translate the sequence information coded in mRNAs into correctly assembled poly-peptide chains. The decoding/translation of genetic information is based on the recognition of a respective codon by its corresponding tRNA anticodon triplet.
The lab is focusing on understanding the molecular mechanisms that lead to the specific base modifications in anticodons of tRNAs. These modifications have a strong influence on the efficiency and accuracy of the codon-anticodon pairing and therefore regulate the translational rates and folding dynamics of protein synthesis. Recent findings have shown that alterations of these modification pathways play important roles in the onset of certain neurodegenerative diseases and cancer.
Heddle Lab | Bionanonauka i Biochemia
NKT Lab Molecular | Mechanisms of Disease
Kantyka Lab | Proteolysis and Post-translational Modification of Proteins
KIND Lab | Kinase Inhibition and Nanotechnology for Diabetes
Ptak Lab I Laboratorium Biologii Rozwoju
Tomasz Lab I Genomika Strukturalna i Funkcjonalna
The Dioscuri Centre for Modelling of Posttranslational Modifications (from May 2023) - Mateusz Sikora, PhD
Wiadomości UJ Wiadomości UJ
"Perły nauki" awarded to M.Sc. eng. Witold Wydmański from the Małopolska Centre of Biotechnology of Jagiellonian University.
The Ministry of Education and Science has launched the first edition of "Perły Nauki", the successor of "Diamentowy Grant". Witold Wydmański, M.Sc. eng, from the Bioinformatics Research Group of the Malopolska Centre of Biotechnology, is one of the 98 winners of the "Perły Nauki". The purpose of this competition is to support exceptionally talented undergraduates or students in their third or fourth year of a unified master's programme. Candidates' projects must receive at least two positive reviews from external experts to be eligible for funding.
Zespół prof. Krzysztofa Pyrcia w międzynarodowej sieci HERA
Komisja Europejska za pośrednictwem Urzędu ds. Gotowości i Reagowania na Stany Zagrożenia Zdrowia (The Health Emergency Preparedness and Response Authority - HERA) utworzyła Europejską Sieć Naukową DURABLE, która ma wesprzeć Unię Europejską w przygotowaniach i reagowaniu na zagrożenia biologiczne i zagrożenia zdrowia oraz w ocenie wpływu i wyborze optymalnych środków
Jak nasze enzymy chronią się same
Protein S-persulfidation (P-SSH) is recognized as a common posttranslational modification. It occurs under basal conditions and is often observed to be elevated under stress conditions. However, the mechanism(s) by which proteins are persulfidated inside cells have remained unclear.
Understanding photosynthesis at atomic resolution
Scientists from the Faculty of Biochemistry, Biophysics and Biotechnology (FBBB) and the Małopolska Centre of Biotechology (MCB) of the Jagiellonian University Krakow teamed up to understand photosynthesis in plants at the atomic level. In detail, the Department of Molecular Biophysics and the Max Planck Research Group determined high-resolution cryo-EM structures of cytochrome b6f, one of the key membrane protein complex in photosynthesis. This complex transfers electrons between plastoquinol and plastocyanin to link functionally plant photosystems, thereby securing electron flow and efficiency of photosynthesis.
Jagiellonian University Professor Receives Leverhulme International Professorship Award
Professor Jonathan Heddle, a Principal Investigator based at the Malopolska Centre of Biotechnology (MCB), has been awarded a an approx. 23 million PLN Leverhulme International Professorship award.
Ground-breaking studies into the structure of the Elongator complex
Wobble uridine carboxymethylation at the tRNAs anticodon is essential for correct protein synthesis. In archaea and bacteria the modification reaction is catalyzed by the Elp3 enzyme, while in eukaryotes the enzyme is a part of the large multi-subunit Elongator complex. The latest work of scientists from the Malopolska Centre of Biotechnology (MCB/UJ) describes the first high resolution cryo-electron microscopy (cryo-EM) structure of Elongator, which sheds light on the role of the Elp456 subcomplex
93 scientists from Jagiellonian University were listed on the TOP 2% ranking of the world's best scientists, including Prof. Krzysztof Pyrć of the Malopolska Center of Biotechnology
The ranking - compiled by Stanford University in cooperation with the publishing house Elsevier and the SciTech Strategies company - evaluates, among other things, the scholars' scientific achievements based on a bibliometric index
Journal Cover for MCB researchers
Recent work of the Bionanoscience and Biochemistry Lab at the Malopolska Centre of Biotechnology has been featured on a journal cover
The MetaSUB consortium's history: worldwide tracking of urban microorganisms
The MetaSUB Consortium, founded in 2015, is a global consortium with an interdisciplinary team of clinicians, scientists, bioinformaticians, engineers, and designers, with members from more than 100 countries across the globe. This network has continually collected samples from urban and rural sites including subways and transit systems, sewage systems, hospitals, and other environmental sampling. These collections have been ongoing since.
The use of phototropins, which are plant blue light photoreceptors, to manipulate the photosynthetic efficiency and increase plant productivity.
Optogenetics is the latest and the most promising tool for medicine and neuroscience, but not only! It also finds other novel applications.
An ancient protein shields enzymes against oxidative stress. Researchers from MBC UJ publish groundbreaking findings in "The EMBO Journal".
Persulfidation is a unique posttranslational protein modification that protects our cells and proteomes against oxidative stress and ageing. Very recent work from the Malopolska Centre of Biotechnology (MCB UJ) shows that this small chemical modification is installed by a cellular protein, called Ubiquitin related modifier 1 (or short Urm1).
"COVID-19 drug practices risk antimicrobial resistance evolution" Dr Pawel Labaj (MCB JU) and a group of scientists associated with the MetaSUB consortium publish in The Lancet Microbe
Antimicrobial resistance is one of the biggest challenges facing modern medicine. Because the management of COVID-19 is increasingly dependent on pharmacological interventions, there is greater risk for accelerating the spread of antimicrobial resistance. A study in a tertiary hospital environment revealed concerning colonisation patterns of microbes during extended periods. It also highlighted the diversity of antimicrobial resistance gene reservoirs in hospitals.