On May 24, 2024, the Jagiellonian University celebrated the 10th anniversary of the Małopolska Centre of Biotechnology (MCB). The event marked a vibrant decade since the centre's establishment on May 13, 2014, by former Rector Professor Wojciech Nowak
Protein synthesis is heavily affected by the presence of various modifications in tRNAs. Wobble uridines in the anticodon stem loop are modified by a large cellular machine called Elongator. Genomic mutations in this macromolecular complex lead to the onset of severe human diseases. The latest work of scientists from the Malopolska Centre of Biotechnology (MCB) of the Jagiellonian University describes the first high-resolution cryo-electron microscopy (cryo-EM) structures of human Elongator and its mechanism of action.