Dubin Lab | Protein Crystallography
We are primarily interested in studying the interactions of proteins and low-molecular substances in the topic of carcinogenesis and bacterial pathogenesis. Currently we realize our own projects involving structural characterization of kinases of essential role cancer, p53 pathway, bacterial proteases of unknown catalytic mechanism and staphylococcal proteases. In parallel to the crystallographic studies we also develop aptamer selection techniques (especially single-stranded DNA) against targets of importance in cancer. In addition to our own research, we are also involved in broad scientific collaboration and cooperation with the industry on other subjects whenever problem scan be solved by X-ray crystallography of proteins. We invite anyone interested in collaboration.
More information about Dubin Lab
Glatt Lab | Max Planck Research Group
We study different translation control mechanisms, which regulate the production of specific sets of proteins by chemical modifications of tRNA molecules. Every protein in the cell is produced by the ribosome, which uses transfer RNA (tRNA) molecules to translate the sequence information coded in mRNAs into correctly assembled poly-peptide chains. The decoding/translation of genetic information is based on the recognition of a respective codon by its corresponding tRNA anticodon triplet.
The lab is focusing on understanding the molecular mechanisms that lead to the specific base modifications in anticodons of tRNAs. These modifications have a strong influence on the efficiency and accuracy of the codon-anticodon pairing and therefore regulate the translational rates and folding dynamics of protein synthesis. Recent findings have shown that alterations of these modification pathways play important roles in the onset of certain neurodegenerative diseases and cancer.
Heddle Lab | Bionanonauka i Biochemia
NKT Lab Molecular | Mechanisms of Disease
Kantyka Lab | Proteolysis and Post-translational Modification of Proteins
KIND Lab | Kinase Inhibition and Nanotechnology for Diabetes
Ptak Lab I Laboratorium Biologii Rozwoju
Tomasz Lab I Genomika Strukturalna i Funkcjonalna
The Dioscuri Centre for Modelling of Posttranslational Modifications (from May 2023) - Mateusz Sikora, PhD
Student of the Jagiellonian University joins EMBL Heidelberg
Jakub Jeżowski, student of a joint programme of the the Małopolska Centre of Biotechnology (MCB) and the Faculty of Biochemistry, Biophysics and Biotechnology, has been awarded an EMBL fellowship for predoctoral researchers, allowing him to join the EMBL International PhD Programme and conduct his PhD thesis at EMBL Heidelberg.
How to make a protein from methylated mRNA
“Transcription” is a cellular process that allows genetic information to flow from DNA to mRNA. During a subsequent step, called “translation”, the resulting mRNA molecules are translated into amino acid chains that fold into cellular proteins and carry out almost all functions in our bodies. This basic principle becomes more intricate by the existence of naturally occurring RNA modifications, and extensive scientific efforts around the globe are underway to decipher their precise role.
Dr Barbara Pucelik and mgr Aleksandra Synowiec in the group of outstanding young scientists with MEiN scholarships for 2023
Naukowcy z MCB wśród nagrodzonych podczas uroczystości obchodów 20-lecia działalności Centrum Transferu Technologii CITTRU
Viruses, bacteria and public health: an analysis of the risks at the European Games 2023 in Krakow
In less than a month, the Kraków-Malopolska European Games, the biggest sporting event in the country's history, will begin. From 21 June to 2 July, the best athletes from 48 European countries will compete for medals in 29 disciplines. According to scientists from the Malopolska Centre of Biotechnology at Jagiellonian University, this is an excellent opportunity to study the impact of organising such a large event and the arrival of a large number of athletes, coaches, activists and fans on the broader health of Krakow's residents.
Researchers from the MCB, Jagiellonian University, are at the forefront of studying the most unique posttranslational modification in the human proteome
"Perły nauki" awarded to M.Sc. eng. Witold Wydmański from the Małopolska Centre of Biotechnology of Jagiellonian University.
The Ministry of Education and Science has launched the first edition of "Perły Nauki", the successor of "Diamentowy Grant". Witold Wydmański, M.Sc. eng, from the Bioinformatics Research Group of the Malopolska Centre of Biotechnology, is one of the 98 winners of the "Perły Nauki". The purpose of this competition is to support exceptionally talented undergraduates or students in their third or fourth year of a unified master's programme. Candidates' projects must receive at least two positive reviews from external experts to be eligible for funding.
Zespół prof. Krzysztofa Pyrcia w międzynarodowej sieci HERA
Komisja Europejska za pośrednictwem Urzędu ds. Gotowości i Reagowania na Stany Zagrożenia Zdrowia (The Health Emergency Preparedness and Response Authority - HERA) utworzyła Europejską Sieć Naukową DURABLE, która ma wesprzeć Unię Europejską w przygotowaniach i reagowaniu na zagrożenia biologiczne i zagrożenia zdrowia oraz w ocenie wpływu i wyborze optymalnych środków
Jak nasze enzymy chronią się same
Protein S-persulfidation (P-SSH) is recognized as a common posttranslational modification. It occurs under basal conditions and is often observed to be elevated under stress conditions. However, the mechanism(s) by which proteins are persulfidated inside cells have remained unclear.
Understanding photosynthesis at atomic resolution
Scientists from the Faculty of Biochemistry, Biophysics and Biotechnology (FBBB) and the Małopolska Centre of Biotechology (MCB) of the Jagiellonian University Krakow teamed up to understand photosynthesis in plants at the atomic level. In detail, the Department of Molecular Biophysics and the Max Planck Research Group determined high-resolution cryo-EM structures of cytochrome b6f, one of the key membrane protein complex in photosynthesis. This complex transfers electrons between plastoquinol and plastocyanin to link functionally plant photosystems, thereby securing electron flow and efficiency of photosynthesis.
Jagiellonian University Professor Receives Leverhulme International Professorship Award
Professor Jonathan Heddle, a Principal Investigator based at the Malopolska Centre of Biotechnology (MCB), has been awarded a an approx. 23 million PLN Leverhulme International Professorship award.
Ground-breaking studies into the structure of the Elongator complex
Wobble uridine carboxymethylation at the tRNAs anticodon is essential for correct protein synthesis. In archaea and bacteria the modification reaction is catalyzed by the Elp3 enzyme, while in eukaryotes the enzyme is a part of the large multi-subunit Elongator complex. The latest work of scientists from the Malopolska Centre of Biotechnology (MCB/UJ) describes the first high resolution cryo-electron microscopy (cryo-EM) structure of Elongator, which sheds light on the role of the Elp456 subcomplex