Protein synthesis is heavily affected by the presence of various modifications in tRNAs. Wobble uridines in the anticodon stem loop are modified by a large cellular machine called Elongator. Genomic mutations in this macromolecular complex lead to the onset of severe human diseases. The latest work of scientists from the Malopolska Centre of Biotechnology (MCB) of the Jagiellonian University describes the first high-resolution cryo-electron microscopy (cryo-EM) structures of human Elongator and its mechanism of action.
W renomowanym czasopiśmie „Nucleic Acids Research”, wydawanym od 1974 roku przez Oxford University Press, ukazał się artykuł poświęcony kompleksowi nsp14, nap16 i nsp10, który jest odpowiedzialny za metylację koronawirusowego RNA. Publikacja jest efektem pracy naukowców z Małopolskiego Centrum Biotechnologii UJ, prowadzonej pod kierunkiem prof. Krzysztofa Pyrć oraz dr Anny Czarnej, w ścisłej współpracy z Instytutem Helmholtza w Monachium.
Dr Mateusz Sikora from the Małopolska Centre of Biotechnology of the Jagiellonian University (JU MCB) has developed a novel approach to predict how sugars form shields around proteins. This new computational approach, GlycoSHIELD, was created as a result of Polish-German collaboration within the framework of the Max Planck Dioscuri programme, in a Dioscuri Centre established in 2023 at the MCB as well as collaboration with the National Institute of Health and Medical Research (Inserm) in Paris and the Academia Sinica (Taiwan).