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Institutional positions

Regular recruitment - complementing call (7 openings - deadline 22nd September 2021)

Go to the How to apply page to learn how to apply to the Doctoral Programme and get to the project.

Plant Molecular Biology Laboratory

Dr. Kenji Yamada
1) Project title:Gene Regulatory Mechanism for the Mustard Oil Bomb Defence System of ER Bodies in Brassicaceae

Project description: Plants have developed sophisticated defence systems to adapt to changes in the environment. Brassicaceae (cabbage) family plants produce unique subcellular structure, namely endoplasmic reticulum (ER) bodies, for chemical defence against animal herbivores. The successful candidate will join a project that aims to understand detailed molecular mechanisms for ER body-based defence system. The project includes analysis of transcriptional regulation for ER body formation, plant defence level with insect-plant or fungi-plant interaction assays, identification of new regulatory genes in the defence system, cell biological and physiological analysis of the defence system.

Developmental Biology Laboratory

Prof. Grażyna Ptak
1) Project title:Effect of exosomes secreted by normal and compromised embryos on their implantation and long term health of offspring.

Project description: Based on our recent report (Arena et al., 2021, PNAS Mar 9;118(10):e2018362118) the project will establish the influence of embryonic exosomes on the implantation process. The student will be introduced to the production of various embryo models characterized by compromised developmental ability (such as androgenotes, parthenogenotes, embryos from parents at advanced age) in order to study their implantation and post-natal health. We are seeking a motivated Ph.D. candidate that is interested in developmental origin of heath and disease (DOHAD) and reproductive medicine. The student will perform oocyte micromanipulations, IVF, embryo culture, mouse  surgeries, molecular and spectroscopic (CARS) analysis of embryos and reproductive tissues. The project is based on a collaborative network with the University of Wurzburg (Germany). International secondments and additional funding might become available for the student during the course of the project.

Max Planck Laboratory

Dr. Sebastian Glatt 
1) Project title:The role of epitranscriptomic marks on translation elongation

Project description: We plan to study ribosomes of prokaryotic and eukaryotic origin by single particle cryo-EM during their translation elongation cycle. In particular, we aim to take advantage of available in vitro translation and RNA modification systems to study the role of individual mRNA, tRNA and rRNA modification during the transitions from initiation, elongation and termination. Furthermore, we would like to define the roles of unique elongation and termination factors during these transitions and their dependency on specific RNA modifications. The project will include an international collaboration partner at the MPI for Biophysical Chemistry (Goettingen, Germany).

The research will be carried out within the framework of the ERC Consolidator grant “tRNAslation”

2) Project title:Structural characterization of tRNA thiolation in eukaryotes

Project description: We will intensify our existing efforts to structurally and functionally characterize the two main anticodon modification cascades targeting U34 bases in eukaryotic tRNAs. In detail, we are interested in understanding the complex that selects specific tRNAs for thiolation and in parallel mediates the final sulfur transfer reaction. In addition, we have discovered a specific physiological linkage between the large macromolecular complex that catalyses the C5 modification and components of the thiolate pathway. The project will use single particle Cryo-EM to structurally characterize the individual proteins in complex with the substrates, metabolites and the specific protein interaction partners. The project will include an international collaboration partner at the University at Bern (Bern, Switzerland).

The research will be carried out within the framework of the ERC Consolidator grant “tRNAslation”

Protein Crystallography Research Group

Prof. Grzegorz Dubin / Dr. Anna Czarna
1) Project title:Structural biology of diabetic kinases

Project description: The project aims to discover new inhibitors for Dyrk kinase family kinases relevant in diabetes and to associate interaction partners involved in the beta cell proliferation and function. The project involves  protein biochemistry, biophysics, enzymology, X-ray crystallography, characterization of protein-protein interactions within the kinome and phospho-kinome and cell localization studies. The research is carried out in an international and national collaborations. We expect to better understand the mechanism of the proliferation and function of the beta cells and develop new set of inhibitors that would modulate their function for future pharmacological intervention.

Microbial Genomics Group

Dr hab. Rafał Mostowy
1) Project title:Investigating factors that determine host range of bacteriophages infecting Klebsiella pneumoniae.

Project description: The student will use a combination of genome informatics and experimental microbiology to understand factors that contribute to host range of Klebsiella phages. The project will be based on (i) comparative genomics of large collections of bacterial genomes and prophages therein, and (ii) experimental work to induce selected prophages and examine their host rage against a wide range of bacterial isolates. By comparing the infection genotype (bioinformatics) and phenotype (laboratory work), the successful candidate will provide novel insight into the fundamental understanding of host range in Klebsiella prophages. Experimental work will be carried out in collaboration with the laboratory of Prof. Zuzanna Drulis-Kawa at University of Wroclaw.

Protein Crystallography Research Group

Prof. Grzegorz Dubin
1) Project title: Understanding the structural biology of coronaviruses

Project description: Coronaviruses are lurking in mammals for decades. Prior outbreaks have been largely ignored, but the current pandemics demonstrates the devastating potential of this family of viruses. The project aims at understanding the structural and functional proteins within coronaviruses with the ultimate goal of developing effective inhibitors of viral proliferation. The project is carried out in collaboration with the largest coronavirus laboratory in Poland which provides functional assays at BSL3 level and in international collaborations. The successful candidate will get a chance to support the studies primary in the fields of structural biology and inhibitor screening.

Select research topic and apply. Active week before deadline.