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Institutional positions

Regular recruitment - complementing call (number of positions to be announced; deadline 22nd September 2021)

Go to the How to apply page to learn how to apply to the Doctoral Programme and get to the project.

Max Planck Laboratory

Dr. Sebastian Glatt 
1) Project title:The role of epitranscriptomic marks on translation elongation

Project description: We plan to study ribosomes of prokaryotic and eukaryotic origin by single particle cryo-EM during their translation elongation cycle. In particular, we aim to take advantage of available in vitro translation and RNA modification systems to study the role of individual mRNA, tRNA and rRNA modification during the transitions from initiation, elongation and termination. Furthermore, we would like to define the roles of unique elongation and termination factors during these transitions and their dependency on specific RNA modifications. The project will include an international collaboration partner at the MPI for Biophysical Chemistry (Goettingen, Germany).

The research will be carried out within the framework of the ERC Consolidator grant “tRNAslation”

2) Project title:Structural characterization of tRNA thiolation in eukaryotes

Project description: We will intensify our existing efforts to structurally and functionally characterize the two main anticodon modification cascades targeting U34 bases in eukaryotic tRNAs. In detail, we are interested in understanding the complex that selects specific tRNAs for thiolation and in parallel mediates the final sulfur transfer reaction. In addition, we have discovered a specific physiological linkage between the large macromolecular complex that catalyses the C5 modification and components of the thiolate pathway. The project will use single particle Cryo-EM to structurally characterize the individual proteins in complex with the substrates, metabolites and the specific protein interaction partners. The project will include an international collaboration partner at the University at Bern (Bern, Switzerland).

The research will be carried out within the framework of the ERC Consolidator grant “tRNAslation”

Microbial Genomics Group

Dr hab. Rafał Mostowy
1) Project title:Investigating factors that determine host range of bacteriophages infecting Klebsiella pneumoniae.

Project description: The student will use a combination of genome informatics and experimental microbiology to understand factors that contribute to host range of Klebsiella phages. The project will be based on (i) comparative genomics of large collections of bacterial genomes and prophages therein, and (ii) experimental work to induce selected prophages and examine their host rage against a wide range of bacterial isolates. By comparing the infection genotype (bioinformatics) and phenotype (laboratory work), the successful candidate will provide novel insight into the fundamental understanding of host range in Klebsiella prophages. Experimental work will be carried out in collaboration with the laboratory of Prof. Zuzanna Drulis-Kawa at University of Wroclaw.

 

The list of positions is not complete at the moment. Please watch for updates.