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Institutional positions

Submission deadline - 11 July 2022

Go to the How to apply page to learn how to apply to the Doctoral Programme and get to the project.

Plant-Microorganism Interactions Group

Supervisor: dr hab. Piotr Rozpądek

1) Project title: Plant-microbial interactions in plant response to environmental stressors

Plant associated microorganisms play a significant role in plant adaptation to the environment. Several aspects of the hosts metabolism are integrated and mutually regulated by the metabolisms of the plant inherent microbiota. The vast majority of these regulatory mechanisms are not known. Their understanding will bring us closer to more efficient plant engineering for agriculture and phytoremediation of polluted environments.

 

 

 

 

 

 

 

 

Protein Crystallography Research Group

Supervisor: Prof. dr hab. Grzegorz Dubin

2) Project title: Structural and functional characterization of peroxisomal protein transport system (PEX)

Peroxisomal transport system (PEX) translocates functional enzymes from the cytoplasm into the peroxisomes. Several dozen PEX proteins are involved in translocation of fully folded cargo enzymes through peroxisomal membrane, but this intriguing process is currently poorly understood at the mechanistic level, a topic of vivid current investigation. The project is carried out in collaboration with Helmholtz Centrum in Munich, Technical University in Munich, Bochum University and University of Warsaw.

 

 

 

 

 

 

 

Development of β-cells organoids

Supervisor: dr Anna Czarna

Diabetes is one of the most common diseases of civilization and has become a major health burden worldwide. In the last century, there has been an exponential increase in the incidence of diabetes due to current lifestyle, constant exposure to stress and/or equally strong genetic predisposition. In recent years, much attention has been focused on the role of DYRK1A kinase in β-cell proliferation and its potential as a therapeutic target for the treatment of diabetes. The inhibitors studied by our group are potential regulatory agents that restore pancreatic β-cell mass and the secretory and regulatory functions of this organ. Recent advances in human pluripotent stem cell (hiPSC) technology enable efficient differentiation of hiPSCs into specific cells and provide an excellent platform for disease modeling, drug screening and regenerative approaches. Our group (Kinase Inhibition and Nanotechnology for Diabetes (KIND) research group) differentiates hiPSCs into iPSC-derived β-cells that can produce insulin.  The iPSC-derived β-cells are evaluated for drug response to discover compounds suitable for optimal treatment of diabetes. 
This project focuses on creating a protein-based matrix to more efficiently prepare hiPSC-derived β-cell organoids. This idea combines tissue engineering with the development of organic surface coating materials to facilitate better growth and efficient differentiation of organoids.