Grant funded positions (deadline - summer 2021; please watch for updates)
Bionanoscience and Biochemistry Laboratory
Dr. Jonathan Heddle
1) Project title: Extending the library of programmable protein cages
Project description: The successful candidate will work with a dedicated and motivated team working at the frontiers of protein nanoscience developing new protein structures based on our recent discoveries published in Nature (https://doi.org/10.1038/s41586-019-1185-4). You will develop and characterize new ways of programming protein cage structures ultimately building protein nanorobotics with potential applications in medicine and beyond.
Microbial Genomics Group
Dr hab. Rafał Mostowy
1) Project title: Examining the role of horizontal gene transfer in evolution of bacteriophages.
Project Description: The student will use a combination of computational approaches (genome informatics, phylogenetics, structural bioinformatics) to examine how horizontal gene transfer shapes bacteriophage genomes. The project will be based on large datasets of viral genomes, coming from different sources, infecting bacteria of Klebsiella pneumoniae and its closely related species. The successful candidate will be expected to develop new approaches based on phylogenetic reconciliation to reconcile phage evolution at different levels, from domains to proteins to genomes and populations.
2) Project title: Investigating factors that determine host range of bacteriophages infecting Klebsiella pneumoniae.
Project description: The student will use a combination of genome informatics and experimental microbiology to understand factors that contribute to host range of Klebsiella phages. The project will be based on (i) comparative genomics of large collections of bacterial genomes and prophages therein, and (ii) experimental work to induce selected prophages and examine their host rage against a wide range of bacterial isolates. By comparing the infection genotype (bioinformatics) and phenotype (laboratory work), the successful candidate will provide novel insight into the fundamental understanding of host range in Klebsiella prophages. Experimental work will be carried out in collaboration with the laboratory of Prof. Zuzanna Drulis-Kawa at University of Wroclaw.
The list of open positions for this call is not completed at this point. Further openings within grants will be announced in the future. Please visit our webpage regularly to learn about new opportunities for joining our Institute.