Grant funded positions (5 openings; deadline 20th July)
Go to the How to apply page to learn how to apply to the Doctoral Programme and get to the project.
Maestro 11, NCN, dr hab. Jonathan Heddle, prof. UJ, Connecting Artificial Protein Cages
1) Project title: Extending the library of programmable protein cages
Project description: The successful candidate will work with a dedicated and motivated team working at the frontiers of protein nanoscience developing new protein structures based on our recent discoveries published in Nature (https://doi.org/10.1038/s41586-019-1185-4). You will develop and characterize new ways of programming protein cage structures ultimately building protein nanorobotics with potential applications in medicine and beyond.
2) Project title: Delivering and tracking artificial protein cages in cells
Project description:The successful candidate will work with a dedicated and motivated team working at the frontiers of protein nanoscience developing new protein structures based on our recent discoveries published in Nature (https://doi.org/10.1038/s41586-019-1185-4). You will develop new ways of filling programmable protein cage structures with therapeutically useful molecules, ultimately building smart medical protein nanorobotics.
Dr. Yusuke Azuma
1) Project title: Encapsidic production of difficult-to-express proteins
Project description: The research project will explore the capability of protein cages to serve as multifunctional storage compartments for proteins that are otherwise difficult to produce in bacterial systems, through redesign and evolution of a cage-forming lumazine synthases. The new protein cage-based technology will contribute significantly to the development of diverse protein-related research fields ranging from basic biophysical characterization to protein therapeutics.
Plant Molecular Biology Laboratory
Dr. Shino Goto-Yamada
1) Project title: molecular insight into the mechanism of peroxisome degradation via autophagy in land plants
Project description: Peroxisome is one of the essential organelles in the photosynthetic process, while this compartment is prone to be oxidized and become toxic components in plant cells. This project aims to understand the molecular mechanisms of degradation system of peroxisomes via autophagy by using a general model plant Arabidopsis and one of the basal lineages, Marchantia polymorpha. We are seeking a motivated candidate interested in our project based on plant physiology and molecular cell biology. Background in molecular biological experiments with Marchantia polymorpha will be an advantage.
Protein Crystallography Research Group
Dr. Anna Czarna
1) Project title: Restoration of β-cell function via inhibition of diabetic kinome
Project description: This project will characterize tool compounds with dual activity against 2 kinase targets implicated in diabetes. Understanding the interaction of the compounds with the kinases will be characterized through structural studies using both crystallography and NMR. The functional characterization will use disease relevant cell-systems including three-dimensional models (3D) models. The aim of the project is to determine whether dual inhibition of the two kinases is important for the survival and recovery of β-cell proliferation and insulin secretion.