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Institutional positions

Submission deadline - 28 November 2021

Go to the How to apply page to learn how to apply to the Doctoral Programme and get to the project.

Protein Crystallography Research Group

Prof. Grzegorz Dubin
1) Project title: Structural and functional characterization of peroxisomal protein transport system (PEX)
Project description: Peroxisomal transport system (PEX) translocates functional enzymes from the cytoplasm into the peroxisomes. Several dozen PEX proteins are involved in translocation of fully folded cargo enzymes through peroxisomal membrane, but this intriguing process is currently poorly understood at the mechanistic level, a topic of vivid current investigation. The project is carried out in collaboration with Helmholtz Centrum in Munich, Technical University in Munich, Bochum University and University of Warsaw.

Plant Molecular Biology Laboratory

Dr. Kenji Yamada
2) Project title:Gene Regulatory Mechanism for the Mustard Oil Bomb Defence System of ER Bodies in Brassicaceae
Project description: Plants have developed sophisticated defence systems to adapt to changes in the environment. Brassicaceae (cabbage) family plants produce unique subcellular structure, namely endoplasmic reticulum (ER) bodies, for chemical defence against animal herbivores. The successful candidate will join a project that aims to understand detailed molecular mechanisms for ER body-based defence system. The project includes analysis of transcriptional regulation for ER body formation, plant defence level with insect-plant or fungi-plant interaction assays, identification of new regulatory genes in the defence system, cell biological and physiological analysis of the defence system.

Protein Crystallography Research Group

Prof. Grzegorz Dubin/Dr. Anna Czarna
3)
Project title: Structural biology of diabetic kinases
Project description: The project aims to discover new inhibitors for Dyrk kinase family kinases relevant in diabetes and to associate interaction partners involved in the beta cell proliferation and function. The project involves  protein biochemistry, biophysics, enzymology, X-ray crystallography, characterization of protein-protein interactions within the kinome and phospho-kinome and cell localization studies. The research is carried out in an international and national collaborations. We expect to better understand the mechanism of the proliferation and function of the beta cells and develop new set of inhibitors that would modulate their function for future pharmacological intervention.

Protein Crystallography Research Group

Prof. Grzegorz Dubin
4) Project title: Understanding the structural biology of coronaviruses
Project description: Coronaviruses are lurking in mammals for decades. Prior outbreaks have been largely ignored, but the current pandemics demonstrates the devastating potential of this family of viruses. The project aims at understanding the structural and functional proteins within coronaviruses with the ultimate goal of developing effective inhibitors of viral proliferation. The project is carried out in collaboration with the largest coronavirus laboratory in Poland which provides functional assays at BSL3 level and in international collaborations.

The successful candidate will get a chance to support the studies primary in the fields of structural biology and inhibitor screening.

Select research topic and apply by submitting documents to: biomedical.phd@uj.edu.pl. Active 4 weeks before deadline.