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Genetic Research and Nutrigenomics Group

Group Leader

Dr Iwona Wybrańska

email: iwona.wybanska@uj.edu.pl

MCB, Gronostajowa 7A St.

Research area

Despite the major advances in understanding disease in the post-genomic era, the majority of all drugs and nutrients are still only effective in a limited number of patients. From a clinical perspective, implementing knowledge-based decisions on what therapeutics or nutrients to use for which patients and, if relevant, in which combinations, is extremely challenging. The aspiration to provide more effective therapeutic interventions tailored to individuals or groups of individuals with common molecular phenotypes remains unfulfilled because of the variable response of individuals to such interventions. Our aim is to deliver novel concepts for disease-mechanism based patient stratification to address the need for stratified or personalised therapeutic interventions. The concept integrates multidimensional and longitudinal data and harnesses the power of -omics, including pharmacogenomics and nutrigenomics, biomedicine systems approaches, network analysis and computational modelling. The concept of stratification will be validated in pre-clinical and clinical studies of civilization diseases, taking into account gender differences.

Main scientific interest:

  1. The role of labile products of arterial wall in development of atherosclerosis and restenosis, with special interest in nitric oxide and growth factors; genetics of apo AI, the role of NO and arachidonic acid derivatives in reverse cholesterol transport.
  2. Genetic background of obesity, metabolic syndrome, atherosclerosis, hypertension, neurological disorders, and other risk factors for civilization diseases.
  3. Influence of food and nutrition on health – study of genes expression in animal models.
  4. New biomarkers for health for modern diagnostics – susceptibility gens and its influence on health and disease
  5. Stem cells usage for regenerative medicine – differentiation into osteoblastic lineage of human ASCs from subcutaneous fat tissue on nanoporous TiO2
  6. Personalized medicine – influence of genetic background to a better therapeutic stratification
  7. Newest trends in clinical diagnostics, pharmacogenomics, nutrigenomics and genetics in service for health, and well understanding modern therapy and precision medicine.

Other activity

  1. Education and expertise on international level
    ​Drawing up scientific and educational materials for the e-learning course entitled: "Gene Polymorphisms and Responsiveness to Diets" for students and doctoral students of 20 partners from EU countries participating in European Nutrigenomic network of excellence;
    Involving in propagating Framework Programs by the European Union in new member countries - Participation in the business trip of representatives of the European Union Countries representatives under sb's management of commissioner Paterman in the Ukraine in 2006.
    Expert evaluator of the European Commission for scientific projects in the area health and food for 6, and 7th Framework. Expert evaluator NCBiR, NCN and Pol-Norwegian projects. Reviewer of articles in scientific journals.
  2. Organization of workshops and congresses:
    Member of organising commettee sympozjum: "Homeostasis and defining health - challenge tests in a nutritional context "Cork, Ireland, 16 May - 18 May 2007;
    "Medycyna precyzyjna – czy możemy leczyć w oparciu o genotyp? Kraków, 12 December 2015 President of scientific committee.
  3. Since 2010 delegate of the Ministry of Education as a national expert, participating in the creation of a program of Community research JPI HDHL "Food and Health".

Publication

  1. Beneficial Effect of Voluntary Exercise on Experimental Colitis in Mice Fed a High-Fat Diet: The Role of Irisin, Adiponectin and Proinflammatory Biomarkers. Mazur-Bialy AI, Bilski J, Wojcik D, Brzozowski B, Surmiak M, Hubalewska-Mazgaj M, Chmura A, Magierowski M, Magierowska K, Mach T, Brzozowski T. Nutrients. 2017 Apr 20;9(4). pii: E410. doi: 10.3390/nu9040410.
  2. Nitric oxide, afferent sensory nerves, and antioxidative enzymes in the mechanism of protection mediated by tricarbonyldichlororuthenium(II) dimer and sodium hydrosulfide against aspirin-induced gastric damage. Magierowski M, Hubalewska-Mazgaj M, Magierowska K, Wojcik D, Sliwowski Z, Kwiecien S, Brzozowski T. J Gastroenterol. 2017 Feb 25. doi: 10.1007/s00535-017-1323-4. [
  3. Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations. Magierowski M, Magierowska K, Hubalewska-Mazgaj M, Sliwowski Z, Pajdo R, Ginter G, Kwiecien S, Brzozowski T. Molecules. 2017 Feb 15;22(2). pii: E295. doi: 10.3390/molecules22020295.

Study on genetic and epigenomic diversity of civilization diseases:

  1. Kuśmierska-Urban K, Rytlewski K, Huras H, Wybrańska I. Association of single nucleotide polymorphism rs7579169 with hypertension disorders during pregnancy and perinatal outcome. Neuro Endocrinol Lett. 2015;36(3):282-7.
  2. Szopa M, Wolkow J, Matejko B, Skupien J, Klupa T, Wybrańska I, Trznadel-Morawska I, Kiec-Wilk B, Borowiec M, Malecki MT Prevalence of Retinopathy in Adult Patients with GCK-MODY and HNF1A-MODY. Exp Clin Endocrinol Diabetes. 2015 Oct;123(9):524-8. doi: 10.1055/s-0035-1559605. Epub 2015 Aug 4.
  3. Zapała B, Płatek T, Wybrańska I. A novel TAZ gene mutation and mosaicism in a Polish family with Barth syndrome. Ann Hum Genet. 2015 May;79(3):218-24. doi: 10.1111/ahg.12108. Epub 2015 Mar 16.
  4. Pokrywka M, Kieć-Wilk B, Polus A, Wybrańska I. DNA methylation in obesity. Postepy Hig Med Dosw (Online). 2014 Nov 27;68:1383-91.
  5. Delgado-Lista J, Perez-Martinez P, García-Rios A, Phillips CM, Williams CM, Gulseth HL, Helal O, Blaak EE, Kiec-Wilk B, Basu S, Drevon CA, Defoort C, Saris WH, Wybranska I, Riserus U, Lovegrove JA, Roche HM, Lopez-Miranda J. Pleiotropic effects of TCF7L2 gene variants and its modulation in the metabolic syndrome: from the LIPGENE study. Atherosclerosis. 2011 Jan;214(1):110-6. doi: 10.1016/j.atherosclerosis.2010.10.027. Epub 2010 Nov 3
  6. Elliott R, Pico C, Dommels Y, Wybranska I, Hesketh J, Keijer J. Nutrigenomic approaches for benefit-risk analysis of foods and food components: defining markers of health. Br J Nutr. 2007 Dec;98(6):1095-100. Epub 2007 Aug 3.
  7. Wybranska I, Malczewska-Malec M, Partyka L, Kiec-Wilk B, Kosno K, Leszczynska-Golabek I, Zdzienicka A, Gruca A, Kwasniak M, Dembinska-Kiec A. Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR). Clin Chem Lab Med. 2007;45(9):1124-32.
  8. Szopa M, Malczewska-Malec M, Wybrańska I, Kieć-Wilk B. Variants of adiponectin gene as risk factors for the metabolic syndrome. Przegl Lek. 2009;66(5):257-62

Study on molecular mechanisms civilization diseases:

  1. Kostogrys RB, Johann C, Czyżyńska I, Franczyk-Żarów M, Drahun A, Maślak E, Jasztal A, Gajda M, Mateuszuk Ł, Wrobel TP, Baranska M, Wybrańska I, Jezkova K, Nachtigal P, Chlopicki S. Characterisation of Atherogenic Effects of Low Carbohydrate, High Protein Diet (LCHP) in ApoE/LDLR-/- Mice. J Nutr Health Aging. 2015 Aug;19(7):710-8. doi: 10.1007/s12603-015-0543-7.
  2. Wybranska I, Polus A, Mikolajczyk M, Knapp A, Sliwa A, Zapala B, Staszel T, Dembinska-Kiec A Apoptosis-related gene expression in glioblastoma (LN-18) and medulloblastoma (Daoy) cell lines. Hum Cell. 2013 Dec;26(4):137-48. doi: 10.1007/s13577-011-0029-9. Epub 2013 Sep 15.
  3. Stępień E, Stankiewicz E, Zalewski J, Godlewski J, Zmudka K, Wybrańska I. Number of microparticles generated during acute myocardial infarction and stable angina correlates with platelet activation. Arch Med Res. 2012 Jan;43(1):31-5. doi: 10.1016/j.arcmed.2012.01.006. Epub 2012 Feb 2.
  4. Stępień E, Gruszczyński K, Kapusta P, Kowalik A, Wybrańska I. Plasma centrifugation does not influence thrombin-antithrombin and plasmin-antiplasmin levels but determines platelet microparticles count. Biochem Med (Zagreb). 2015 Jun 5;25(2):222-9. doi: 10.11613/BM.2015.022. eCollection 2015
  5. Zapała B, Staszel T, Kieć-Wilk B, Polus A, Knapp A, Wybrańska I, Kaczyński Ł, Dembińska-Kieć A.  Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities. Przegl Lek. 2011;68(7):372-7.
  6. Staszel T, Zapała B, Polus A, Sadakierska-Chudy A, Kieć-Wilk B, Stępień E, Wybrańska I, Chojnacka M, Dembińska-Kieć A. Role of microRNAs in endothelial cell pathophysiology. Pol Arch Med Wewn. 2011 Oct;121(10):361-6.
  7. Razny U, Kiec-Wilk B, Polus A, Wator L, Dyduch G, Partyka L, Bodzioch M, Tomaszewska R, Wybranska I. The adipose tissue gene expression in mice with different nitric oxide availability. J Physiol Pharmacol. 2010 Oct;61(5):607-18.
  8. Hesketh J, Wybranska I, Dommels Y, King M, Elliott R, Pico C, Keijer J. Nutrient-gene interactions in benefit-risk analysis.  Br J Nutr. 2006 Jun;95(6):1232-6.

Regeneration medicine

  1. Wybrańska K, Paczesny J, Serejko K, Sura K, Włodyga K, Dzięcielewski I, Jones ST, Śliwa A, Wybrańska I, Hołyst R, Scherman OA, Fiałkowski M. Gold-oxoborate nanocomposites and their biomedical applications. ACS Appl Mater Interfaces. 2015 Feb 25;7(7):3931-9. doi: 10.1021/am508979y. Epub 2015 Feb 1
  2. Malec K1, Góralska J1, Hubalewska-Mazgaj M2, Głowacz P1, Jarosz M3, Ciałowicz U1, Brzewski P4, Jędruch T3, Wybrańska I1, Jaskuła M3Effects of anodic nanoporous titanium oxide on human adipose derived stem cells in press in International Journal of Nanomedicine, 2016.