Our investigation focuses on what affects the development of mammalian embryo in long term perspectives (i.e. Developmental Origins of Health and Disease, DOHaD). The influence of assisted reproduction technologies and of parental aging on life-long health status of the offspring as well as transgenerational inheritance of the disease, are within our primary interests.
Our investigation focuses on what affects the development of mammalian embryo in long term perspectives (i.e. Developmental Origins of Health and Disease, DOHaD). The influence of assisted reproduction technologies and of parental aging on life-long health status of the offspring as well as transgenerational inheritance of the disease, are within our primary interests. Furthermore, our research is aimed at understanding mechanisms activated during blastocyst growth and implantation. The use of sophisticated experimental models, including delayed implantation, mono-parental embryos, oocyte and embryo manipulations and culture in vitro allow us to achieve our research objectives.
Maria Florencia Heber, PhD - assistant professor
Simona Bisogno, MSc - PhD student
Hafsa Gulzar, MSc – PhD student
Richard Musson, MSc – PhD student
Kinga Fic, PhD student - Behaviourist theory acolyte
Kamil Blicharski, MSc – technician
Julia Krzenek – student/volunteer
We are always seeking for interested and highly motivated Master, PhD or Postdoc candidates. Please contact us for further details: email@example.com.
National Science Centre – SONATINA 2022/44/C/NZ4/00076 – PI: PI: Maria Florencia Heber – Title: Transgenerational inheritance of Liver Disease in mouse offspring conceived by Assisted Reproduction Technologies.
National Science Centre - OPUS 2021/41/B/NZ3/03507 – PI: Grażyna Ptak - Size matters: how a blastocyst's size affects offspring health
National Science Centre - OPUS 2019/35/B/NZ4/03547 – PI: Grażyna Ptak - Advanced parental age and assisted reproductive techniques: evaluation of the risk of neurodevelopmental disorders in the offspring in three generations
National Science Centre – PRELUDIUM 2019/35/N/NZ3/03213 - PI: Łukasz Gąsior - Title: Influence of embryonic diapause on the heritability of mitochondrial mutations in a mouse model of obesity
National Science Centre - PRELUDIUM 2018/29/N/NZ3/02177 – PI: Roberta Arena – Title: Regulation of autophagy by paternal and maternal genome during Embryonic Diapause
National Science Centre - OPUS 2016/21/B/NZ3/03631 – PI: Grażyna Ptak – Title: Influence of intracellular lipids in the oocyte and embryo on the duration of the Embryonic Diapause
POB BioS - JU, 2021-2022 - PI: Maria Florencia Heber – Title: Assisted reproductive technologies effects on placental inflammation and brain development
National Agency for Academic Exchange (NAWA) fellowship to Maria Florencia Heber (GA ULM/2019/1/00097/U/00001)
Ministry of Science and Higher Education - DIAMOND GRANT DI2018/017548 – PI: Kinga Fic – Title: Risk assessment of neurodevelopmental disorders in mouse offspring obtained by Intra Cytoplasmic Sperm Injection (ICSI- Intracytoplasmic Sperm Injection) using sperm from aged males.
Horizon 2020 - TWINN-2015 GA 692185 - acronym ERAofART - PI: Grażyna Ptak - Title: Epigenetic Risk Assessment of Assisted Reproductive Technologies
DNA damage in preimplantation embryos and gametes: specification, clinical relevance and repair strategies. Musson R, Gąsior Ł, Bisogno S, Ptak GE. Hum Reprod Update. 2022 May 2;28(3):376-399. doi: 10.1093/humupd/dmab046.
Ribosomal DNA methylation in human and mouse oocytes increases with age. Potabattula R, Trapphoff T, Dittrich M, Fic K, Ptak GE, Dieterle S, Haaf T. Aging (Albany NY). 2022 Feb 14;14(3):1214-1232. doi: 10.18632/aging.203891.
Species-Specific Paternal Age Effects and Sperm Methylation Levels of Developmentally Important Genes. Prell A, Sen MO, Potabattula R, Bernhardt L, Dittrich M, Hahn T, Schorsch M, Zacchini F, Ptak GE, Niemann H, Haaf T. Cells. 2022 Feb 19;11(4):731. doi: 10.3390/cells11040731.
Lipid droplets in mammalian eggs are utilized during embryonic diapause. Arena R, Bisogno S, Gąsior Ł, Rudnicka J, Bernhardt L, Haaf T, Zacchini F, Bochenek M, Fic K, Bik E, Barańska M, Bodzoń-Kułakowska A, Suder P, Depciuch J, Gurgul A, Polański Z, Ptak GE. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2018362118. doi: 10.1073/pnas.2018362118.
The effects of assisted reproduction technologies on metabolic health and disease. Heber MF, Ptak GE. Biol Reprod. 2021 Apr 1;104(4):734-744. doi: 10.1093/biolre/ioaa224.
Perturbations of the hepatic proteome behind the onset of metabolic disorders in mouse offspring developed following embryo manipulation. Zacchini F, Heber MF, Arena R, Radczuk N, Jankowska U, Ptak GE. Theriogenology. 2021 Sep 1;171:119-129. doi: 10.1016/j.theriogenology.2021.05.022.
Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline. Potabattula R, Zacchini F, Ptak GE, Dittrich M, Müller T, El Hajj N, Hahn T, Drummer C, Behr R, Lucas-Hahn A, Niemann H, Schorsch M, Haaf T. Aging Cell. 2020 Aug;19(8):e13181. doi: 10.1111/acel.13181.
Mouse single oocyte imaging by MALDI-TOF MS for lipidomics. Bodzon-Kulakowska A, Arena R, Mielczarek P, Hartman K, Kozoł P, Gibuła-Tarlowska E, Wrobel TP, Gąsior Ł, Polański Z, Ptak GE, Suder P. Cytotechnology. 2020 Jun;72(3):455-468. doi: 10.1007/s10616-020-00393-9.
Assessing the epigenetic risks of assisted reproductive technologies: a way forward. Zacchini F, Sampino S, Stankiewicz AM, Haaf T, Ptak GE. Int J Dev Biol. 2019;63(3-4-5):217-222. doi: 10.1387/ijdb.180402gp.