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Virogenetics | Pyrc Lab

Our research efforts are aimed to understand the virus biology

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Leader | Virogenetics | Laboratory of Virology

Prof. Krzysztof Pyrć

Prof. Krzysztof Pyrć

Leader of the Virology Laboratory at the Malopolska Centre of Biotechnology of the Jagiellonian University


Virologist. Graduated from Jagiellonian University (M.Sc.), University of Amsterdam (Ph.D.), and University of Lodz (habilitation). In January 2019 received the title of Professor in the field of biological sciences. He specializes in emerging RNA viruses (mainly coronaviruses and flaviviruses), with particular emphasis on mechanisms of infection and the development of new therapeutic strategies. Head of the Laboratory of Virology at the Malopolska Centre of Biotechnology, Jagiellonian University. A certified project manager.

Leader of Virogenetics research group, supervisor, and promoter of students and Ph.D. students. Authored ~120 publications in journals as Nature Medicine, Science Translational Medicine, PNAS, Science Signaling. Reviewer and expert in science funding institutions in Poland and abroad (Horizon2020, ERC, FNP, NCN, and others). Author of several patent applications and patents, on the basis of which 2 spin-off companies have already been established (Acatavir and StartIt Vet). Manager and coordinator of numerous research grants, including under Horizon2020, IMI2, European Cooperation in Science and Technology, NCN, FNP, NCBIR, and MNiSW, as well as grants funded by commercial entities.

Deputy chairman of the Polish Academy of Sciences think-tank. Member of governmental advisory teams supporting the fight with the pandemic on the local, national and European Levels. Expert of the AOTMiT in the field of SARS-CoV-2 therapy and diagnostics.

Phone: +48 692 696 863
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Monitoring the genetic variability of SARS-CoV-2 virus in Poland



The mainstream of our research concerns interactions between the virus and the host cell. We seek cellular receptors and activating factors, which define the species and tissue specificity; we delineate virus internalization routes and decipher the viral interactome in the cell to understand its crosstalk with our body. Our work focuses on the tissue level (3D tissue cultures, organoids), single cell level, and atomic level (cryoEM, crystallography). We translate our basic research into the application, and over years I have developed a successful applicatory program focusing on new antivirals.


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