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Molecular Mechanisms of Disease lab

Research topics at Molecular Mechanisms of Disease Group: 

iPSCs disease modeling in a dish headed by Dr. Neli Kachamakova-Trojanowska 
Pancreatic cancer research – role of the microenvironment headed by Dr. Monika Jakubowska

Head of the group:

Dr. Neli Kachamakova-Trojanowska
neli.kachamakova-trojanowska@uj.edu.pl, 
phone: 12 664 6468, room 2/24

 

 

 

 

Team members:

Dr. Monika Jakubowska                                                         
Leader of the pancreatic cancer research                               
monika.jakubowska@uj.edu.pl                                           
phone: 12 664 6468; room 2/24 

 

 

 

Dr. Damian Klóska
topic: iPSCs disease modeling in a dish
damian.kloska@uj.edu.pl
phone: 12 664 6468; room 2/24

 

 

PhD student Kinga Stopa
kinga.stopa@doctoral.uj.edu.pl
(topic: pancreatic cancer) 

 

 

 

PhD student Daria Krzysztofik
daria.krzysztofik@doctoral.uj.edu.pl  
(topic: pancreatic cancer)

 

 

 

PhD student Dawid Skoczek
dawid.skoczek@doctoral.uj.edu.pl
(topic: iPSCs disease modeling)

 

 

 

Students:

Dominika Drapała
Filip Łoziński
Aldona Szewczyk

Funding:

2022-2024 Project PRELUDIUM 20, awarded to Daria Krzysztofik: "Long-term exposure to high copper: does it affect the production of pancreatic digestive enzymes?"
2021-2025 Project Sonata-Bis headed by Dr. Neli Kachamakova-Trojanowska: “Molecular background of microvascular complications in HNF1A-MODY patients: induced pluripotent stem cells as disease modeling tool”
2021-2022 POB BIOS Minigrant awarded to Dr. Monika Jakubowska
Title: "Copper misbalance and impaired exocrine pancreatic functions - ex vivo analyses of the Atp7b toxic milk mouse model" 
2018-2021 Project OPUS headed by Dr. Neli Kachamakova-Trojanowska:“ Editing of HNF1A gene in human induced pluripotent stem cells with CRISPR/Cas9 for disease modeling of endothelial (dys)function in maturity onset diabetes of the young (MODY)” 
2018-2020 Project HOMING headed by Dr. Monika Jakubowska: “Targeting mechanisms of pancreatic cancer resistance against therapy: specific role of tumor microenvironment”

Recent publications:
1. Skoczek et al., Maturity Onset Diabetes of the Young-New Approaches for Disease Modelling, Int J Mol Sci. 2021.
2. Kachamakova-Trojanowska et al., HIF-1 stabilization exerts anticancer effects in breast cancer cells in vitro and in vivo. Biochem Pharmacol. 2020 
3. Białopiotrowicz et al., Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells. Cancers (Basel). 2020
4. Szade et al., Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells. EMBO Rep. 2020
5. Rozga et al., Novel engineered TRAIL-based chimeric protein strongly inhibits tumor growth and bypasses TRAIL resistance. Int J Cancer. 2019
6. Kachamakova-Trojanowska et al., Human iPSCs-Derived Endothelial Cells with Mutation in HNF1A as a Model of Maturity-Onset Diabetes of the Young, Cells. 2019
7. Szade et al., Cobalt protoporphyrin IX increases endogenous G-CSF and mobilizes HSC and granulocytes to the blood. EMBO Mol Med. 2019
8. Nowak et al., Atorvastatin and Conditioned Media from Atorvastatin-Treated Human Hematopoietic Stem/Progenitor-Derived Cells Show Proangiogenic Activity In Vitro but Not In Vivo. Mediators Inflamm. 2019
9. Mucha et al., Development and characterization of a new inhibitor of heme oxygenase activity for cancer treatment. Arch Biochem Biophys. 2019
10. Šmíd et al., Heme Oxygenase-1 May Affect Cell Signalling via Modulation of Ganglioside Composition. Oxid Med Cell Longev. 2018.
11. Kachamakova-Trojanowska et al., Molecular profiling of regulatory T cells in pulmonary sarcoidosis. J Autoimmun. 2018
12. Mucha et al., Pharmacological versus genetic inhibition of heme oxygenase-1 - the comparison of metalloporphyrins, shRNA and CRISPR/Cas9 system. Acta Biochim Pol. 2018
13. Stepniewski et al., Heme oxygenase-1 affects generation and spontaneous cardiac differentiation of induced pluripotent stem cells. IUBMB Life. 2018