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Molecular Mechanisms of Disease lab

Team members:

Dr. Neli Kachamakova-Trojanowska: neli.kachamakova-trojanowska@uj.edu.pl, phone: 12 664 6468, room 2/24

Dr. Monika Jakubowska: monika.jakubowska@uj.edu.pl, phone: 12 664 6468; room 2/24

PhD students:

MSc Kinga Stopa: kinga.stopa@student.uj.edu.pl

MSc Daria Krzysztofik: daria.krzysztofik@doctoral.uj.edu.pl

MSc students:

BSc Dawid Skoczek

 

 

 

Research topics

Disease-in-a-dish

Pancreatic cancer – specific role of tumor microenvironment

 

Funding:

2018-2021 Project OPUS headed by Dr. Neli Kachamakova-Trojanowska:“Editing of HNF1A gene in human induced pluripotent stem cells with CRISPR/Cas9 for disease modeling of endothelial (dys)function in maturity onset diabetes of the young (MODY)”

2018-2020 Project HOMING headed by Dr. Monika Jakubowska:“Targeting mechanisms of pancreatic cancer resistance against therapy: specific role of tumor microenvironment”

Recent publications:

1. Kachamakova-Trojanowska et al., HIF-1 stabilization exerts anticancer effects in breast cancer cells in vitro and in vivo. Biochem Pharmacol. 2020

2. Białopiotrowicz et al., Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells. Cancers (Basel). 2020

3. Szade et al., Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells. EMBO Rep. 2020

4. Rozga et al., Novel engineered TRAIL-based chimeric protein strongly inhibits tumor growth and bypasses TRAIL resistance. Int J Cancer. 2019

5. Kachamakova-Trojanowska et al., Human iPSCs-Derived Endothelial Cells with Mutation in HNF1A as a Model of Maturity-Onset Diabetes of the Young, Cells. 2019

6. Szade et al., Cobalt protoporphyrin IX increases endogenous G-CSF and mobilizes HSC and granulocytes to the blood. EMBO Mol Med. 2019

7. Nowak et al., Atorvastatin and Conditioned Media from Atorvastatin-Treated Human Hematopoietic Stem/Progenitor-Derived Cells Show Proangiogenic Activity In Vitro but Not In Vivo. Mediators Inflamm. 2019

8. Mucha et al., Development and characterization of a new inhibitor of heme oxygenase activity for cancer treatment. Arch Biochem Biophys. 2019

9. Šmíd et al., Heme Oxygenase-1 May Affect Cell Signalling via Modulation of Ganglioside Composition. Oxid Med Cell Longev. 2018.

10. Kachamakova-Trojanowska et al., Molecular profiling of regulatory T cells in pulmonary sarcoidosis. J Autoimmun. 2018

11. Mucha et al., Pharmacological versus genetic inhibition of heme oxygenase-1 - the comparison of metalloporphyrins, shRNA and CRISPR/Cas9 system. Acta Biochim Pol. 2018

12. Stepniewski et al., Heme oxygenase-1 affects generation and spontaneous cardiac differentiation of induced pluripotent stem cells. IUBMB Life. 2018

13. Nowak et al., Murine Bone Marrow Mesenchymal Stromal Cells Respond Efficiently to Oxidative Stress Despite the Low Level of Heme Oxygenases 1 and 2. Antioxid Redox Signal. 2018