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Information on the competition – PhD student at Malopolska Centre of Biotechnology, Laboratory of Virology (SONATA BIS, National Science Center)

What is this about:
The research project aims to characterize a newly identified mechanism contributing to HIV latency and reactivation.
The Human Immunodeficiency Virus (HIV) is the cause of the Acquired Immunodeficiency Syndrome (AIDS) and is responsible for the devastating pandemic that affects around 36.7 million people around the world. Despite effective antiretroviral therapy (ART), the virus remains in the body for a lifetime. Major reason that a cure for HIV continues to elude us is that the virus hides away in cells, forming a persistent reservoir in which the virus is dormant (i.e. latent), and in such cells the virus is not visible to the immune system and to antiretroviral therapy. Consequently, latency persists, cannot be eliminated, and represent a major hurdle to finding a cure. With no vaccine on horizon, several strategies are currently proposed to fight latent HIV. One of them is “shock and kill” that involves induction of latent viruses (HIV reactivation, “shock”) using latency-reversing agents (LRAs) while maintaining antiretroviral therapy (“kill”) to prevent new spreading infection. However, there is increasing body of evidence showing that this strategy is not efficient enough in reactivating the virus. We have recently identified a novel block that impede the efficient action of LRAs.  In this project we propose to further characterize this novel block. 
Results obtained within this project will be very important for designing new, more potent “shock” protocols to purge the latent reservoir.
PhD student will participate in the research work under the SONATA BIS project entitled "Characterization of the role of MATR3 in HIV latency and reactivation".
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Position: PhD student
Unit: Malopolska Centre of Biotechnology
The deadline for submitting documents: 31.08.2020
Date of manufacture: 23.07.2020

Details of announcing in the attachment.


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