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The Bionanoscience and Biochemistry laboratory is recruiting a doctoral student in project entitled “Structural basis of transmissible fluoroquinolone resistance”

The Bionanoscience and Biochemistry laboratory is recruiting a doctoral student for a fully-funded position with a duration of up to three years. The successful candidate will work on an NCN-funded project entitled “Structural basis of transmissible fluoroquinolone resistance”.

The Bionanoscience and Biochemistry laboratory is recruiting a doctoral student for a fully-funded position with a duration of up to three years. The successful candidate will work on an NCN-funded project entitled “Structural basis of transmissible fluoroquinolone resistance” to uncover the mechanisms of transmissible fluoroquinolone resistance in Mycobacterium tuberculosis.

 

 

 

While working on the project, you will use cryo-electron microscopy to study the interactions of fluoroquinolone resistance protein MfpA with Mycobacterial DNA gyrase. The project offers an opportunity to carry out basic molecular biology research (DNA topoisomerase biology) with a real-world impact (antimicrobial drug resistance). You will learn relevant techniques of protein production and structural biology techniques, particularly cryo-EM. You will also have the opportunity to participate in silico drug design, screening and activity testing.

More information about the Bionanoscience and Biochemistry laboratory is available on Heddle Lab website.

The ideal candidate should fulfil the following criteria:

  • Possess master, master of an engineer or equivalent degree in molecular biology, structural biology, biochemistry or related areas;
  • Be motivated to study biochemistry and structural biology;
  • Have strong work commitment and the ability for independent work;
  • Have excellent written and oral communication skills in English;
  • Have good skills in work management and experimental record keeping;
  • Able to work across disciplines and be willing to gain expertise in new areas;
  • Able to work as a part of the team and with international collaborators.

For the details of the competition and required documentation go to the website of Doctoral School of Exact and Natural Sciences at the Jagiellonian University.