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Information on the competition – PhD student at Malopolska Centre of Biotechnology

Information on the competition – PhD student at Malopolska Centre of Biotechnology, Laboratory of Virology (SONATA BIS, National Science Center).

Research description:
The research project aims to characterize a newly identified mechanism contributing to HIV latency and reactivation.
The Human Immunodeficiency Virus (HIV) is the cause of the acquired Acquired Immunodeficiency Syndrome (AIDS) and is responsible for the devastating pandemic that affects around 36.7 million people around the world. Despite effective antiretroviral therapy (ART), the virus remains in the body for a lifetime. Major reason that a cure for HIV continues to elude us is that the virus hides away in cells, forming a persistent reservoir in which the virus is dormant (i.e. latent), and in such cells the virus is not visible to the immune system and to antiretroviral therapy. Consequently, latency persists, cannot be eliminated and represent a major hurdle to finding a cure. With no vaccine on horizon, several strategies are currently proposed in order to fight latent HIV. One of them is “shock and kill” that involves induction of latent viruses (HIV reactivation, “shock”) using latency-reversing agents while maintaining antiretroviral therapy (“kill”) in order to prevent new spreading infection. However, there is increasing body of evidence showing that this strategy is not efficient enough in reactivating the virus due to blocks that are not efficiently overcome by latency-reversing agents (LRAs). In this context, we have recently identified a novel block that impede the efficient action of LRAs.  In this project we propose to further characterize this novel block. Results obtained within this project will be very important for designing new, more potent “shock” protocols to purge the latent reservoir.
PhD student will participate in the research work under the SONATA BIS project entitled "Characterization of the role of MATR3 in HIV latency and reactivation".
For more information, please visit: https://mcb.uj.edu.pl/en_GB/annakulapacurar

Requirements:
A scholarship may be awarded to a person who has the status of a PhD student

The ideal candidate should:
- possess MSc degree in the field of biotechnology, biology or related fields of life sciences,
- have great commitment and motivation to the research work being carried out,
- show a good level of independence,
- have basic knowladge in molecular biology techniques,
- experience in working with eukaryotic cells is welcome,
- experience in working with infectious material is welcome,
- have good written and oral communication skills in English 


Position: PhD student
Unit: Malopolska Centre of Biotechnology
The deadline for submitting documents: 30.06.2019
Date of manufacture: 15.05.2019
 
Details of announcing in the attachment.